Naringin alleviates periodontitis via direct AMPK/Nrf2 activation and NLRP3 inhibition, amplified by gut microbiota/Arg-Gln modulation

Periodontitis, driven by oral-gut microbiota dysbiosis and NLRP3 inflammasome activation, lacks effective natural therapeutic strategies. ...

Activation of CD40 in tumors reprograms the tumor microenvironment

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and ...

Blocking mitochondrial leucine transamination enhances T-cell activation and improves T-cell immunity against OVA-producing EL4 lymphoma

Pharmaceutical chemicals and antibodies N-acetyl-leucine amide (NALA), a competitive antagonist of leucine, was purchased from ...

Cytosolic CTH senses bacterial lipoproteins and drives noncanonical inflammasome activation

Kawai, T., Ikegawa, M., Ori, D. & Akira, S. Decoding Toll-like receptors: recent insights and ...

Macrophage-derived MBL restrains coronavirus-induced pulmonary inflammation by modulating metabolic regulator PKM2-mediated NLRP3 activation

The precise mechanisms governing innate immune response to coronaviruses remain elusive. Our study reveals that ...

CD1d functions as a ligand for PIRA2 to drive macrophage activation in nonalcoholic fatty liver disease

Liver inflammation is a key driver of nonalcoholic fatty liver disease (NAFLD) and its progressive ...

Author Correction: Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging

Cite this article Langston, P.K., Vijaya Raghavan, J., Benoist, C. et al. Author Correction: Piezo1-dependent ...

Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging

Furman, D. et al. Chronic inflammation in the etiology of disease across the life span. ...

Thromboxane receptor activation in dendritic cells mitigates sepsis by suppressing S100a8/a9-mediated neutrophil recruitment

Human participants Sepsis patients and controls were recruited at Tianjin Medical University General Hospital. Sepsis ...

Limited duodenal immune activation in functional dyspepsia is not linked to spinal sensory neuron activation

Study participants Patients with FD (Rome IV criteria) were recruited from the University Hospitals Leuven ...