SLC38A4 promotes Kupffer cell phagocytosis and suppresses tumor liver metastasis

Cell culture Mouse melanoma cell line B16F10 (cat. SCSP-5233), mouse CRC cell line MC38 (cat. ...

Foxp3 drives context-dependent epigenetic programs that define regulatory T cell molecular identity and function | Science Immunology

Foxp3 integrates cell-intrinsic and environmental contexts with epigenetic programs to establish Treg cell molecular identity ...

Citraconate preserves T cell stemness and antitumor immunity | Science Immunology

Citraconate preserves stemness, mitigates ferroptosis, and potentiates T cell antitumor immunity by modulating the PDE1-cAMP-ALOX5 ...

Tetrameric STAT5 regulates the formation of immune niche cells to protect stem cell regenerative repair against mucosal inflammation

IBD–UC increased colonic crypt TCRγδ+STAT5+ T cells Using FACS analysis, we examined PBMCs from n = 24 ...

De novo engineered disulfide bond supersedes native interchain linkage to enhance TCR pairing and anti-tumor efficacy in T cell therapy

Baulu E, Gardet C, Chuvin N, Depil S. TCR-engineered T cell therapy in solid tumors: ...

Identification of a distinct cluster of LY6E+ macrophages in esophageal squamous cell carcinoma: functional phenotype, spatial interaction, and prognostic significance

Generation of the ESCC single-cell transcriptomic atlas To characterize the TME in ESCC, we performed ...

CAR-X cell engineering | Nature Reviews Bioengineering

Eshhar, Z., Waks, T., Gross, G. & Schindler, D. G. Specific activation and targeting of ...

Reprogramming of stroma-derived chemokine networks drives the loss of tissue organization in nodal B cell lymphoma

Mapping the spatiocellular principles of lymphoma-induced LN remodeling To decipher the overarching principles that govern ...

The TCR in CAR T cell therapy: use it or lose it?

Goyco Vera D, Waghela H, Nuh M, Pan J, Lulla P. Approved CAR-T therapies have ...

Diagnosed With Advanced Renal Cell Carcinoma: Why You May Want a Second Opinion, and How to Find One

Seeking out a second opinion can give you the confidence that you’re getting the best ...