CAR-adapted PIK3CD base editing enhances T cell anti-tumor potency

Cell lines and culture conditions Cell lines used were luciferase-expressing and GFP-expressing Nalm6 (M.S., Columbia ...

Targeting autocrine retinoic acid signaling by ALDH1A2 inhibition enhances antitumor dendritic cell vaccine efficacy

Cabeza-Cabrerizo, M., Cardoso, A., Minutti, C. M., Pereira da Costa, M. & Reis, E. S. ...

Pathogenic IgE-fated memory B cell responses retain functional plasticity | Science Immunology

Pathogenic B cell responses to allergens are reprogrammed by blockade of IL-4 and IL-13 signaling. ...

Novel anti-ITGA4 monoclonal antibody induces cell death via large pore formation in NK/T-cell lymphoma cells

Shiravand, Y. et al. Immune checkpoint inhibitors in cancer therapy. Front. Oncol. 12, 1234–1245 (2022). ...

WASH regulates B cell signaling, metabolism and function through STAT1

Papa R, Penco F, Volpi S, Gattorno M. Actin remodeling defects leading to autoinflammation and ...

Scarless circular mRNA-based CAR-T cell therapy elicits superior antitumor efficacy

High-yield and scarless cmRNA synthesis via an engineered PIE First, we engineered a new PIE ...

Anti-MSLN chimeric antigen receptor-like NK cell therapy with tumor-penetrating capacity (uCAR-like NK) for solid tumors

Construction and characterization of the bispecific cell engager MSLN×CD16A To construct the bispecific cell engager ...

Role of innate immune and inflammatory signaling in West Nile virus tropism and neuronal and glial cell death

Cell culture Human neural progenitor cells (hNPC) were prepared and cultured as described in Brnic ...

A comparative mathematical modeling study of phenotypic approaches to T cell activation

Feinerman, O., Germain, R. N. & Altan-Bonnet, G. Quantitative challenges in understanding ligand discrimination by ...

CD27 agonism enhances long-lived CD4 T cell vaccine responses critical for antitumor immunity | Science Immunology

CD27 agonism enhances vaccine-induced CD4 T cell responses, enabling durable antitumor immunity not entirely dependent ...