The emerging role of dendritic cells in the tumor microenvironment: from antigen presentation to targeted immunotherapy

The emerging role of dendritic cells in the tumor microenvironment: from antigen presentation to targeted immunotherapy

  • Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med. 1973;137:1142–62.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Galluzzi L, Senovilla L, Vacchelli E, Eggermont A, Fridman WH, Galon J, et al. Trial watch: Dendritic cell-based interventions for cancer therapy. Oncoimmunology. 2012;1:1111–34.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Heras-Murillo I, Adán-Barrientos I, Galán M, Wculek SK, Sancho D. Dendritic cells as orchestrators of anticancer immunity and immunotherapy. Nat Rev Clin Oncol. 2024;21:257–77.

    Article 
    PubMed 

    Google Scholar
     

  • Hinshaw DC, Shevde LA. The tumor microenvironment innately modulates cancer progression. Cancer Res. 2019;79:4557–66.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • B”ttcher JP, Bonavita E, Chakravarty P, Blees H, Cabeza-Cabrerizo M, Sammicheli S. NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control. Cell. 2018;172:1022–37.e14.

    Article 

    Google Scholar
     

  • He D, Wang D, Lu P, Yang N, Xue Z, Zhu X, et al. Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations. Oncogene. 2021;40:355–68.

    Article 
    PubMed 

    Google Scholar
     

  • Del Prete A, Salvi V, Soriani A, Laffranchi M, Sozio F, Bosisio D, et al. Dendritic cell subsets in cancer immunity and tumor antigen sensing. Cell Mol Immunol. 2023;20:432–47.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Moon CY, Belabed M, Park MD, Mattiuz R, Puleston D, Merad M. Dendritic cell maturation in cancer. Nat Rev Cancer. 2025;25:225–48.

    Article 
    PubMed 

    Google Scholar
     

  • Devi KSP, Anandasabapathy N. The origin of DCs and capacity for immunologic tolerance in central and peripheral tissues. Semin Immunopathol. 2017;39:137–52.

    Article 
    PubMed 

    Google Scholar
     

  • Ng LG, Liu Z, Kwok I, Ginhoux F. Origin and heterogeneity of tissue myeloid cells: a focus on GMP-derived monocytes and neutrophils. Annu Rev Immunol. 2023;41:375–404.

    Article 
    PubMed 

    Google Scholar
     

  • Amon L, Lehmann CHK, Heger L, Heidkamp GF, Dudziak D. The ontogenetic path of human dendritic cells. Mol Immunol. 2020;120:122–9.

    Article 
    PubMed 

    Google Scholar
     

  • Liu Z, Wang H, Li Z, Dress RJ, Zhu Y, Zhang S, et al. Dendritic cell type 3 arises from Ly6C+ monocyte-dendritic cell progenitors. Immunity. 2023;56:1761–.e6.

    Article 
    PubMed 

    Google Scholar
     

  • Geissmann F, Manz MG, Jung S, Sieweke MH, Merad M, Ley K. Development of monocytes, macrophages, and dendritic cells. Science. 2010;327:656–61.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu K, Nussenzweig MC. Origin and development of dendritic cells. Immunol Rev. 2010;234:45–54.

    Article 
    PubMed 

    Google Scholar
     

  • Kang BH, Lee HK. Dendritic cell-based immunotherapy in hot and cold tumors. Int J Mol Sci. 2022;23:7325.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • See P, Dutertre C-A, Chen J, Günther P, McGovern N, Irac SE, et al. Mapping the human DC lineage through the integration of high-dimensional techniques. Science. 2017;356:eaag3009.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pittet MJ, Pilato MD, Garris C, Mempel TR. Dendritic cells as shepherds of T cell immunity in cancer. Immunity. 2023;56:2218–30.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Feng J, Pucella JN, Jang G, Alcántara-Hernández M, Upadhaya S, Adams NM, et al. Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells. Immunity. 2022;55:405–.e11.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Møller SH, Wang L, Ho P-C. Metabolic programming in dendritic cells tailors immune responses and homeostasis. Cell Mol Immunol. 2022;19:370–83.

    Article 
    PubMed 

    Google Scholar
     

  • Laoui D, Keirsse J, Morias Y, Van Overmeire E, Geeraerts X, Elkrim Y, et al. The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity. Nat Commun. 2016;7:13720.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Adams NM, Das A, Yun TJ, Reizis B. Ontogeny and function of plasmacytoid dendritic cells. Annu Rev Immunol. 2024;42:347–73.

    Article 
    PubMed 

    Google Scholar
     

  • Musumeci A, Lutz K, Winheim E, Krug AB. What makes a pDC: recent advances in understanding plasmacytoid DC development and heterogeneity. Front Immunol. 2019;10:1222.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang S, Audiger C, Chopin M, Nutt SL. Transcriptional regulation of dendritic cell development and function. Front Immunol. 2023;14:1182553.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kanayama M, Izumi Y, Onai N, Akashi T, Hiraoka Y, Ohteki T. Diverse developmental pathways of lymphoid conventional dendritic cells with distinct tissue distribution and function. Sci Adv. 2025;11:eadt4909.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Que W, Guo W-Z, Li X-K. Manipulation of regulatory dendritic cells for induction transplantation tolerance. Front Immunol. 2020;11:582658.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Guilliams M, Ginhoux F, Jakubzick C, Naik SH, Onai N, Schraml BU, et al. Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny. Nat Rev Immunol. 2014;14:571–8.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sulczewski FB, Maqueda-Alfaro RA, Alcántara-Hernández M, Perez OA, Saravanan S, Yun TJ, et al. Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses. Nat Immunol. 2023;24:1265–80.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu X, Zhu R, Luo Y, Wang S, Zhao Y, Qiu Z, et al. Distinct human Langerhans cell subsets orchestrate reciprocal functions and require different developmental regulation. Immunity. 2021;54:2305–.e11.

    Article 
    PubMed 

    Google Scholar
     

  • Wang Y, Xiang Y, Xin VW, Wang X-W, Peng X-C, Liu X-Q, et al. Dendritic cell biology and its role in tumor immunotherapy. J Hematol Oncol J Hematol Oncol. 2020;13:107.

    Article 
    PubMed 

    Google Scholar
     

  • Ronchese F, Webb GR, Ochiai S, Lamiable O, Brewerton M. How type-2 dendritic cells induce Th2 differentiation: instruction, repression, or fostering T cell-T cell communication?. Allergy. 2025;80:395–407.

    Article 
    PubMed 

    Google Scholar
     

  • Lucarini V, Melaiu O, Tempora P, D’Amico S, Locatelli F, Fruci D. Dendritic cells: behind the scenes of T-cell infiltration into the tumor microenvironment. Cancers. 2021;13:433.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Veglia F, Gabrilovich DI. Dendritic cells in cancer: the role revisited. Curr Opin Immunol. 2017;45:43–51.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bosteels V, Janssens S. Striking a balance: new perspectives on homeostatic dendritic cell maturation. Nat Rev Immunol. 2025;25:125–40.

    Article 
    PubMed 

    Google Scholar
     

  • Patente TA, Pinho MP, Oliveira AA, Evangelista GCM, Bergami-Santos PC, Barbuto JAM. Human dendritic cells: their heterogeneity and clinical application potential in cancer immunotherapy. Front Immunol. 2018;9:3176.

    Article 
    PubMed 

    Google Scholar
     

  • Chen MY, Zhang F, Goedegebuure SP, Gillanders WE. Dendritic cell subsets and implications for cancer immunotherapy. Front Immunol. 2024;15:1393451.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Peng X, He Y, Huang J, Tao Y, Liu S. Metabolism of dendritic cells in tumor microenvironment: for immunotherapy. Front Immunol. 2021;12:613492.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ma T, Chu X, Wang J, Li X, Zhang Y, Tong D, et al. Pan-cancer analyses refine the single-cell portrait of tumor-infiltrating dendritic cells. Cancer Res. 2025. https://doi.org/10.1158/0008-5472.CAN-24-3595.

  • van Vlerken-Ysla L, Tyurina YY, Kagan VE, Gabrilovich DI. Functional states of myeloid cells in cancer. Cancer Cell. 2023;41:490–504.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gerhard GM, Bill R, Messemaker M, Klein AM, Pittet MJ. Tumor-infiltrating dendritic cell states are conserved across solid human cancers. J Exp Med. 2021;218:e20200264.

    Article 
    PubMed 

    Google Scholar
     

  • Huang Q, Wang F, Hao D, Li X, Li X, Lei T, et al. Deciphering tumor-infiltrating dendritic cells in the single-cell era. Exp Hematol Oncol. 2023;12:97.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hansen M, Andersen MH. The role of dendritic cells in cancer. Semin Immunopathol. 2017;39:307–16.

    Article 
    PubMed 

    Google Scholar
     

  • Kvedaraite E, Ginhoux F. Human dendritic cells in cancer. Sci Immunol. 2022;7:eabm9409.

    Article 
    PubMed 

    Google Scholar
     

  • Gardner A, de Mingo Pulido Á, Ruffell B. Dendritic cells and their role in immunotherapy. Front Immunol. 2020;11:924.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bödder J, Zahan T, van Slooten R, Schreibelt G, de Vries IJM, Flórez-Grau G. Harnessing the cDC1-NK cross-talk in the tumor microenvironment to battle cancer. Front Immunol. 2020;11:631713.

    Article 
    PubMed 

    Google Scholar
     

  • León B. Type 2 conventional dendritic cell functional heterogeneity: ontogenically committed or environmentally plastic?. Trends Immunol. 2025;46:104–20.

    Article 
    PubMed 

    Google Scholar
     

  • Cytlak U, Resteu A, Pagan S, Green K, Milne P, Maisuria S, et al. Differential IRF8 transcription factor requirement defines two pathways of dendritic cell development in humans. Immunity. 2020;53:353–.e8.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li J, Zhou J, Huang H, Jiang J, Zhang T, Ni C. Mature dendritic cells enriched in immunoregulatory molecules (mregDCs): A novel population in the tumour microenvironment and immunotherapy target. Clin Transl Med. 2023;13:e1199.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Marciscano AE, Anandasabapathy N. The role of dendritic cells in cancer and anti-tumor immunity. Semin Immunol. 2021;52:101481.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tiberio L, Laffranchi M, Zucchi G, Salvi V, Schioppa T, Sozzani S, et al. Inhibitory receptors of plasmacytoid dendritic cells as possible targets for checkpoint blockade in cancer. Front Immunol. 2024;15:1360291.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Monti M, Ferrari G, Gazzurelli L, Bugatti M, Facchetti F, Vermi W. Plasmacytoid dendritic cells at the forefront of anti-cancer immunity: rewiring strategies for tumor microenvironment remodeling. J Exp Clin Cancer Res CR. 2024;43:196.

    PubMed 

    Google Scholar
     

  • Fu C, Jiang A. Dendritic cells and CD8 T cell immunity in tumor microenvironment. Front Immunol. 2018;9:3059.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hato L, Vizcay A, Eguren I, Pérez-Gracia JL, Rodríguez J, Gállego Pérez-Larraya J, et al. Dendritic cells in cancer immunology and immunotherapy. Cancers. 2024;16:981.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Villani A-C, Satija R, Reynolds G, Sarkizova S, Shekhar K, Fletcher J, et al. Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors. Science. 2017;356:eaah4573.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Segura E, Amigorena S. Inflammatory dendritic cells in mice and humans. Trends Immunol. 2013;34:440–5.

    Article 
    PubMed 

    Google Scholar
     

  • Perez CR, De Palma M. Engineering dendritic cell vaccines to improve cancer immunotherapy. Nat Commun. 2019;10:5408.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mazzoccoli L, Liu B. Dendritic cells in shaping anti-tumor T cell response. Cancers. 2024;16:2211.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang Q, He Y, Luo N, Patel SJ, Han Y, Gao R, et al. Landscape and dynamics of single immune cells in hepatocellular carcinoma. Cell. 2019;179:829–.e20.

    Article 
    PubMed 

    Google Scholar
     

  • Maier B, Leader AM, Chen ST, Tung N, Chang C, LeBerichel J, et al. A conserved dendritic-cell regulatory program limits antitumour immunity. Nature. 2020;580:257–62.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Luri-Rey C, Teijeira Á, Wculek SK, de Andrea C, Herrero C, Lopez-Janeiro A, et al. Cross-priming in cancer immunology and immunotherapy. Nat Rev Cancer. 2025;25:249–73.

    Article 
    PubMed 

    Google Scholar
     

  • Cheng S, Li Z, Gao R, Xing B, Gao Y, Yang Y, et al. A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells. Cell. 2021;184:792–809.e23.

    Article 
    PubMed 

    Google Scholar
     

  • Di Pilato M, Kfuri-Rubens R, Pruessmann JN, Ozga AJ, Messemaker M, Cadilha BL, et al. CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment. Cell. 2021;184:4512–.e22.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Meiser P, Knolle MA, Hirschberger A, de Almeida GP, Bayerl F, Lacher S, et al. A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity. Cancer Cell. 2023;41:1498–.e10.

    Article 
    PubMed 

    Google Scholar
     

  • Bhandarkar V, Dinter T, Spranger S. Architects of immunity: how dendritic cells shape CD8+ T cell fate in cancer. Sci Immunol. 2025;10:eadf4726.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tabarkiewicz J, Rybojad P, Jablonka A, Rolinski J. CD1c+ and CD303+ dendritic cells in peripheral blood, lymph nodes and tumor tissue of patients with non-small cell lung cancer. Oncol Rep. 2008;19:237–43.

    PubMed 

    Google Scholar
     

  • Adhikaree J, Franks HA, Televantos C, Vaghela P, Kaur AP, Walker D, et al. Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition—implications for the next generation of DC vaccines. Oncoimmunology. 2019;8:1593803.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu W, Zhao J, Li Q, Wang Q, Zhou Y, Tong Z. Gastric cancer patients have elevated plasmacytoid and CD1c+ dendritic cells in the peripheral blood. Oncol Lett. 2018;15:5087–92.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lee YS, O’Brien LJ, Walpole CM, Pearson FE, Leal-Rojas IM, Masterman K-A, et al. Human CD141+ dendritic cells (cDC1) are impaired in patients with advanced melanoma but can be targeted to enhance anti-PD-1 in a humanized mouse model. J Immunother Cancer. 2021;9:e001963.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li W, Pan L, Hong W, Ginhoux F, Zhang X, Xiao C, et al. A single-cell pan-cancer analysis to show the variability of tumor-infiltrating myeloid cells in immune checkpoint blockade. Nat Commun. 2024;15:6142.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mellman I, Chen DS, Powles T, Turley SJ. The cancer-immunity cycle: Indication, genotype, and immunotype. Immunity. 2023;56:2188–205.

    Article 
    PubMed 

    Google Scholar
     

  • Yi M, Li T, Niu M, Mei Q, Zhao B, Chu Q, et al. Exploiting innate immunity for cancer immunotherapy. Mol Cancer. 2023;22:187.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhu S, Yang N, Wu J, Wang X, Wang W, Liu Y-J, et al. Tumor microenvironment-related dendritic cell deficiency: a target to enhance tumor immunotherapy. Pharmacol Res. 2020;159:104980.

    Article 
    PubMed 

    Google Scholar
     

  • Saxena M, van der Burg SH, Melief CJM, Bhardwaj N. Therapeutic cancer vaccines. Nat Rev Cancer. 2021;21:360–78.

    Article 
    PubMed 

    Google Scholar
     

  • Fujii S-I, Shimizu K. Exploiting antitumor immunotherapeutic novel strategies by deciphering the cross talk between invariant NKT cells and dendritic cells. Front Immunol. 2017;8:886.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kyrysyuk O, Wucherpfennig KW. Designing cancer immunotherapies that engage T cells and NK cells. Annu Rev Immunol. 2023;41:17–38.

    Article 
    PubMed 

    Google Scholar
     

  • Tang F, Li J, Qi L, Liu D, Bo Y, Qin S, et al. A pan-cancer single-cell panorama of human natural killer cells. Cell. 2023;186:4235–.e20.

    Article 
    PubMed 

    Google Scholar
     

  • Ferlazzo G, Morandi B. Cross-talks between natural killer cells and distinct subsets of dendritic cells. Front Immunol. 2014;5:159.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jacobs B, Gebel V, Heger L, Grèze V, Schild H, Dudziak D, et al. Characterization and manipulation of the crosstalk between dendritic and natural killer cells within the tumor microenvironment. Front Immunol. 2021;12:670540.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Subleski JJ, Wiltrout RH, Weiss JM. Application of tissue-specific NK and NKT cell activity for tumor immunotherapy. J Autoimmun. 2009;33:275–81.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Barry KC, Hsu J, Broz ML, Cueto FJ, Binnewies M, Combes AJ, et al. A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments. Nat Med. 2018;24:1178–91.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cazzetta V, Franzese S, Carenza C, Della Bella S, Mikulak J, Mavilio D. Natural killer-dendritic cell interactions in liver cancer: implications for immunotherapy. Cancers. 2021;13:2184.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhao L, Yang X. Cross talk between natural killer T and dendritic cells and its impact on T cell responses in infections. Front Immunol. 2022;13:837767.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Carroll SL, Pasare C, Barton GM. Control of adaptive immunity by pattern recognition receptors. Immunity. 2024;57:632–48.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity. 2013;39:1–10.

    Article 
    PubMed 

    Google Scholar
     

  • Böttcher JP, Reis e Sousa C. The role of type 1 conventional dendritic cells in cancer immunity. Trends Cancer. 2018;4:784–92.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Spranger S, Dai D, Horton B, Gajewski TF. Tumor-residing Batf3 dendritic cells are required for effector T cell trafficking and adoptive T cell therapy. Cancer Cell. 2017;31:711–.e4.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chandra R, Karalis JD, Liu C, Murimwa GZ, Voth Park J, Heid CA, et al. The colorectal cancer tumor microenvironment and its impact on liver and lung metastasis. Cancers. 2021;13:6206.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Padoan A, Plebani M, Basso D. Inflammation and pancreatic cancer: focus on metabolism, cytokines, and immunity. Int J Mol Sci. 2019;20:676.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Korbecki J, Olbromski M, Dzięgiel P. CCL18 in the progression of cancer. Int J Mol Sci. 2020;21:7955.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Garris CS, Luke JJ. Dendritic cells, the T-cell-inflamed tumor microenvironment, and immunotherapy treatment response. Clin Cancer Res J Am Assoc Cancer Res. 2020;26:3901–7.

    Article 

    Google Scholar
     

  • Moreno Ayala MA, Campbell TF, Zhang C, Dahan N, Bockman A, Prakash V, et al. CXCR3 expression in regulatory T cells drives interactions with type I dendritic cells in tumors to restrict CD8+ T cell antitumor immunity. Immunity. 2023;56:1613–.e5.

    Article 
    PubMed 

    Google Scholar
     

  • You S, Li S, Zeng L, Song J, Li Z, Li W, et al. Lymphatic-localized Treg-mregDC crosstalk limits antigen trafficking and restrains anti-tumor immunity. Cancer Cell. 2024;42:1415–.e12.

    Article 
    PubMed 

    Google Scholar
     

  • Mangana C, Maier BB. Perilymphatic regulatory T cell-dendritic cell interactions represent a novel axis of immunosuppression in cancer. Cancer Cell. 2024;42:1329–31.

    Article 
    PubMed 

    Google Scholar
     

  • Ostrand-Rosenberg S, Sinha P, Beury DW, Clements VK. Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppression. Semin Cancer Biol. 2012;22:275–81.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ji S, Shi Y, Yin B. Macrophage barrier in the tumor microenvironment and potential clinical applications. Cell Commun Signal CCS. 2024;22:74.

    Article 
    PubMed 

    Google Scholar
     

  • Pfirschke C, Zilionis R, Engblom C, Messemaker M, Zou AE, Rickelt S, et al. Macrophage-Targeted therapy unlocks antitumoral cross-talk between IFNγ-secreting lymphocytes and IL12-producing dendritic cells. Cancer Immunol Res. 2022;10:40–55.

    Article 
    PubMed 

    Google Scholar
     

  • Zhang L, Li Z, Skrzypczynska KM, Fang Q, Zhang W, O’Brien SA, et al. Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer. Cell. 2020;181:442–.e29.

    Article 
    PubMed 

    Google Scholar
     

  • Ruffell B, Chang-Strachan D, Chan V, Rosenbusch A, Ho CMT, Pryer N, et al. Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells. Cancer Cell. 2014;26:623–37.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gabrilovich DI, Ostrand-Rosenberg S, Bronte V. Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol. 2012;12:253–68.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li P-H, Kong X-Y, He Y-Z, Liu Y, Peng X, Li Z-H, et al. Recent developments in application of single-cell RNA sequencing in the tumour immune microenvironment and cancer therapy. Mil Med Res. 2022;9:52.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ielpo S, Barberini F, Dabbagh Moghaddam F, Pesce S, Cencioni C, Spallotta F, et al. Crosstalk and communication of cancer-associated fibroblasts with natural killer and dendritic cells: New frontiers and unveiled opportunities for cancer immunotherapy. Cancer Treat Rev. 2024;131:102843.

    Article 
    PubMed 

    Google Scholar
     

  • Huang T-X, Tan X-Y, Huang H-S, Li Y-T, Liu B-L, Liu K-S, et al. Targeting cancer-associated fibroblast-secreted WNT2 restores dendritic cell-mediated antitumour immunity. Gut. 2022;71:333–44.

    Article 
    PubMed 

    Google Scholar
     

  • Pei L, Liu Y, Liu L, Gao S, Gao X, Feng Y, et al. Roles of cancer-associated fibroblasts (CAFs) in anti- PD-1/PD-L1 immunotherapy for solid cancers. Mol Cancer. 2023;22:29.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Plebanek MP, Sturdivant M, DeVito NC, Hanks BA. Role of dendritic cell metabolic reprogramming in tumor immune evasion. Int Immunol. 2020;32:485–91.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang X, Liu J, Cheng Y, Chen K, Chen Y, Zhu H, et al. Metabolic enzyme Suclg2 maintains tolerogenicity of regulatory dendritic cells diffDCs by suppressing Lactb succinylation. J Autoimmun. 2023;138:103048.

    Article 
    PubMed 

    Google Scholar
     

  • Zewdie EY, Edwards GM, Hunter DM, Earp HS, Holtzhausen A. MerTK induces dysfunctional dendritic cells by metabolic reprogramming. Cancer Immunol Res. 2024;12:1268–85.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • de Lima Thomaz L, Peron G, Oliveira J, da Rosa LC, Thomé R, Verinaud L. The impact of metabolic reprogramming on dendritic cell function. Int Immunopharmacol. 2018;63:84–93.

    Article 
    PubMed 

    Google Scholar
     

  • Zou W, Green DR. Beggars banquet: metabolism in the tumor immune microenvironment and cancer therapy. Cell Metab. 2023;35:1101–13.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Corrado M, Frezza C. Glutamine availability unleashes dendritic cells’ anti-tumor power. Cell Chem Biol. 2023;30:1012–4.

    Article 
    PubMed 

    Google Scholar
     

  • Kelly B, O’Neill LAJ. Metabolic reprogramming in macrophages and dendritic cells in innate immunity. Cell Res. 2015;25:771–84.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sen K, Pati R, Jha A, Mishra GP, Prusty S, Chaudhary S, et al. NCoR1 controls immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation. Redox Biol. 2023;59:102575.

    Article 
    PubMed 

    Google Scholar
     

  • Liu X, Yu P, Xu Y, Wang Y, Chen J, Tang F, et al. Metformin induces tolerogenicity of dendritic cells by promoting metabolic reprogramming. Cell Mol Life Sci CMLS. 2023;80:283.

    Article 
    PubMed 

    Google Scholar
     

  • Wu L, Yan Z, Jiang Y, Chen Y, Du J, Guo L, et al. Metabolic regulation of dendritic cell activation and immune function during inflammation. Front Immunol. 2023;14:1140749.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Michaeloudes C, Bhavsar PK, Mumby S, Xu B, Hui CKM, Chung KF, et al. Role of metabolic reprogramming in pulmonary innate immunity and its impact on lung diseases. J Innate Immun. 2020;12:31–46.

    Article 
    PubMed 

    Google Scholar
     

  • Biswas SK. Metabolic reprogramming of immune cells in cancer progression. Immunity. 2015;43:435–49.

    Article 
    PubMed 

    Google Scholar
     

  • Harjunpää H, Somermäki R, Saldo Rubio G, Fusciello M, Feola S, Faisal I, et al. Loss of β2-integrin function results in metabolic reprogramming of dendritic cells, leading to increased dendritic cell functionality and anti-tumor responses. Oncoimmunology. 2024;13:2369373.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jin X, Zhang W, Wang Y, Liu J, Hao F, Li Y, et al. Pyruvate kinase M2 promotes the activation of dendritic cells by enhancing IL-12p35 expression. Cell Rep. 2020;31:107690.

    Article 
    PubMed 

    Google Scholar
     

  • Niveau C, Cettour-Cave M, Mouret S, Sosa Cuevas E, Pezet M, Roubinet B, et al. MCT1 lactate transporter blockade re-invigorates anti-tumor immunity through metabolic rewiring of dendritic cells in melanoma. Nat Commun. 2025;16:1083.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhao Y, Gao C, Liu L, Wang L, Song Z. The development and function of human monocyte-derived dendritic cells regulated by metabolic reprogramming. J Leukoc Biol. 2023;114:212–22.

    Article 
    PubMed 

    Google Scholar
     

  • Jiang L, Fang X, Wang H, Li D, Wang X. Ovarian cancer-intrinsic fatty acid synthase prevents anti-tumor immunity by disrupting tumor-infiltrating dendritic cells. Front Immunol. 2018;9:2927.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • O’Neill LAJ, Pearce EJ. Immunometabolism governs dendritic cell and macrophage function. J Exp Med. 2016;213:15–23.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Guo C, You Z, Shi H, Sun Y, Du X, Palacios G, et al. SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity. Nature. 2023;620:200–8.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hong Y, Manoharan I, Suryawanshi A, Majumdar T, Angus-Hill ML, Koni PA, et al. β-catenin promotes regulatory T-cell responses in tumors by inducing vitamin A metabolism in dendritic cells. Cancer Res. 2015;75:656–65.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Devalaraja S, To TKJ, Folkert IW, Natesan R, Alam MZ, Li M, et al. Tumor-derived retinoic acid regulates intratumoral monocyte differentiation to promote immune suppression. Cell. 2020;180:1098–.e16.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang Z, Liu Q, Che Y, Yuan X, Dai L, Zeng B, et al. Antigen presentation by dendritic cells in tumors is disrupted by altered metabolism that involves pyruvate kinase M2 and its interaction with SOCS3. Cancer Res. 2010;70:89–98.

    Article 
    PubMed 

    Google Scholar
     

  • Wculek SK, Cueto FJ, Mujal AM, Melero I, Krummel MF, Sancho D. Dendritic cells in cancer immunology and immunotherapy. Nat Rev Immunol. 2020;20:7–24.

    Article 
    PubMed 

    Google Scholar
     

  • Bol K, Bloemendal M, Van Willigen W, Schreibelt G, Bree SH, De Goede A, et al. 1078MO MIND-DC: a randomized phase III trial to assess the efficacy of adjuvant dendritic cell vaccination in comparison to placebo in stage IIIB and IIIC melanoma patients. Ann Oncol. 2020;31:S732.

    Article 

    Google Scholar
     

  • Mao K, Tan H, Cong X, Liu J, Xin Y, Wang J, et al. Optimized lipid nanoparticles enable effective CRISPR/Cas9-mediated gene editing in dendritic cells for enhanced immunotherapy. Acta Pharm Sin B. 2025;15:642–56.

    Article 
    PubMed 

    Google Scholar
     

  • Harari A, Graciotti M, Bassani-Sternberg M, Kandalaft LE. Antitumour dendritic cell vaccination in a priming and boosting approach. Nat Rev Drug Discov. 2020;19:635–52.

    Article 
    PubMed 

    Google Scholar
     

  • Kantoff PW, Higano CS, Shore ND, Berger ER, Small EJ, Penson DF, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363:411–22.

    Article 
    PubMed 

    Google Scholar
     

  • Chen J, Duan Y, Che J, Zhu J. Dysfunction of dendritic cells in tumor microenvironment and immunotherapy. Cancer Commun Lond Engl. 2024;44:1047–70.

    Article 

    Google Scholar
     

  • Feng K, Zhang X, Li J, Han M, Wang J, Chen F, et al. Neoantigens combined with in situ cancer vaccination induce personalized immunity and reshape the tumor microenvironment. Nat Commun. 2025;16:5074.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fukushima CM, de Groot J. Updates for newly diagnosed and recurrent glioblastoma: a review of recent clinical trials. Curr Opin Neurol. 2024;37:666–71.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Preusser M, van den Bent MJ. Autologous tumor lysate-loaded dendritic cell vaccination (DCVax-L) in glioblastoma: Breakthrough or fata morgana?. Neuro-Oncol. 2023;25:631.

    Article 
    PubMed 

    Google Scholar
     

  • Gatto L, Di Nunno V, Tosoni A, Bartolini S, Ranieri L, Franceschi E. DCVax-L vaccination in patients with glioblastoma: real promise or negative trial? The debate is open. Cancers. 2023;15:3251.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kyte JA, Aamdal S, Dueland S, Sæbøe-Larsen S, Inderberg EM, Madsbu UE, et al. Immune response and long-term clinical outcome in advanced melanoma patients vaccinated with tumor-mRNA-transfected dendritic cells. Oncoimmunology. 2016;5:e1232237.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Das R, Ge X, Fei F, Parvanian S, Weissleder R, Garris CS. Lipid nanoparticle-mRNA engineered dendritic cell based adoptive cell therapy enhances cancer immune response. Small Methods. 2025;9:e2400633.

    Article 
    PubMed 

    Google Scholar
     

  • Berneman ZN, De Laere M, Germonpré P, Huizing MT, Willemen Y, Lion E, et al. WT1-mRNA dendritic cell vaccination of patients with glioblastoma multiforme, malignant pleural mesothelioma, metastatic breast cancer, and other solid tumors: type 1 T-lymphocyte responses are associated with clinical outcome. J Hematol OncolJ Hematol Oncol. 2025;18:9.

    Article 

    Google Scholar
     

  • Lee K-W, Yam JWP, Mao X. Dendritic cell vaccines: a shift from conventional approach to new generations. Cells. 2023;12:2147.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhou J, Tison K, Zhou H, Bai L, Acharyya RK, McEachern D, et al. STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity. Nature. 2025;643:519–28.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu P, Zhao L, Kroemer G, Kepp O. Conventional type 1 dendritic cells (cDC1) in cancer immunity. Biol Direct. 2023;18:71.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Aliazis K, Christofides A, Shah R, Yeo YY, Jiang S, Charest A, et al. The tumor microenvironment’s role in the response to immune checkpoint blockade. Nat Cancer. 2025;6:924–37.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hu Z, Ma Y, Shang Z, Hu S, Liang K, Liang W, et al. Improving immunotherapy for colorectal cancer using dendritic cells combined with anti-programmed death-ligand in vitro. Oncol Lett. 2018;15:5345–51.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li S, Wang D, Cheng J, Sun J, Kalvakolanu DV, Zhao X, et al. A photodynamically sensitized dendritic cell vaccine that promotes the anti-tumor effects of anti-PD-L1 monoclonal antibody in a murine model of head and neck squamous cell carcinoma. J Transl Med. 2022;20:505.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • De Keersmaecker B, Claerhout S, Carrasco J, Bar I, Corthals J, Wilgenhof S, et al. TriMix and tumor antigen mRNA electroporated dendritic cell vaccination plus ipilimumab: link between T-cell activation and clinical responses in advanced melanoma. J Immunother Cancer. 2020;8:e000329.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang J, Wang L, Guo H, Kong S, Li W, He Q, et al. The role of Tim-3 blockade in the tumor immune microenvironment beyond T cells. Pharmacol Res. 2024;209:107458.

    Article 
    PubMed 

    Google Scholar
     

  • Reinhard K, Rengstl B, Oehm P, Michel K, Billmeier A, Hayduk N, et al. An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors. Science. 2020;367:446–53.

    Article 
    PubMed 

    Google Scholar
     

  • Lövgren T, Wolodarski M, Wickström S, Edbäck U, Wallin M, Martell E, et al. Complete and long-lasting clinical responses in immune checkpoint inhibitor-resistant, metastasized melanoma treated with adoptive T cell transfer combined with DC vaccination. Oncoimmunology. 2020;9:1792058.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sabado RL, Balan S, Bhardwaj N. Dendritic cell-based immunotherapy. Cell Res. 2017;27:74–95.

    Article 
    PubMed 

    Google Scholar
     

  • Dong H, Li Q, Zhang Y, Ding M, Teng Z, Mou Y. Biomaterials facilitating dendritic cell-mediated cancer immunotherapy. Adv Sci Weinh Baden-Wurtt Ger. 2023;10:e2301339.


    Google Scholar
     

  • Dhodapkar MV, Sznol M, Zhao B, Wang D, Carvajal RD, Keohan ML, et al. Induction of antigen-specific immunity with a vaccine targeting NY-ESO-1 to the dendritic cell receptor DEC-205. Sci Transl Med. 2014;6:232ra51.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dolgin E. Cancer vaccines: material breach. Nature. 2013;504:S16–17.

    Article 
    PubMed 

    Google Scholar
     

  • Hodi FS, Giobbie-Hurder A, Adu-Berchie K, Ranasinghe S, Lako A, Severgnini M, et al. First-in-human clinical trial of vaccination with WDVAX, a dendritic cell-activating scaffold incorporating autologous tumor cell lysate, in patients with metastatic melanoma. Cancer Immunol Res. 2025;13:978–89.

    Article 
    PubMed 

    Google Scholar
     

  • Viswanath DI, Liu H-C, Huston DP, Chua CYX, Grattoni A. Emerging biomaterial-based strategies for personalized therapeutic in situ cancer vaccines. Biomaterials. 2022;280:121297.

    Article 
    PubMed 

    Google Scholar
     

  • Lu Q, Kou D, Lou S, Ashrafizadeh M, Aref AR, Canadas I, et al. Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy. J Hematol OncolJ Hematol Oncol. 2024;17:16.

    Article 

    Google Scholar
     

  • Chou P-Y, Lin S-Y, Wu Y-N, Shen C-Y, Sheu M-T, Ho H-O. Glycosylation of OVA antigen-loaded PLGA nanoparticles enhances DC-targeting for cancer vaccination. J Control Release J Control Release Soc. 2022;351:970–88.

    Article 

    Google Scholar
     

  • Goyvaerts C, Breckpot K. The journey of in vivo virus engineered dendritic cells from bench to bedside: a bumpy road. Front Immunol. 2018;9:2052.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Luo J, Mo F, Zhang Z, Hong W, Lan T, Cheng Y, et al. Engineered mitochondria exert potent antitumor immunity as a cancer vaccine platform. Cell Mol Immunol. 2024;21:1251–65.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Daman AW, Antonelli AC, Redelman-Sidi G, Paddock L, Khayat S, Ketavarapu M, et al. Microbial cancer immunotherapy reprograms hematopoiesis to enhance myeloid-driven anti-tumor immunity. Cancer Cell. 2025;S1535-6108:00211–9.


    Google Scholar
     

  • Jneid B, Bochnakian A, Hoffmann C, Delisle F, Djacoto E, Sirven P, et al. Selective STING stimulation in dendritic cells primes antitumor T cell responses. Sci Immunol. 2023;8:eabn6612.

    Article 
    PubMed 

    Google Scholar
     

  • Cao LL, Kagan JC. Targeting innate immune pathways for cancer immunotherapy. Immunity. 2023;56:2206–17.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Régnier P, Vetillard M, Bansard A, Pierre E, Li X, Cagnard N, et al. FLT3L-dependent dendritic cells control tumor immunity by modulating Treg and NK cell homeostasis. Cell Rep. Med. 2023;4:101256.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hammerich L, Marron TU, Upadhyay R, Svensson-Arvelund J, Dhainaut M, Hussein S, et al. Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination. Nat Med. 2019;25:814–24.

    Article 
    PubMed 

    Google Scholar
     

  • Salomon R, Rotem H, Katzenelenbogen Y, Weiner A, Cohen Saban N, Feferman T, et al. Bispecific antibodies increase the therapeutic window of CD40 agonists through selective dendritic cell targeting. Nat Cancer. 2022;3:287–302.

    Article 
    PubMed 

    Google Scholar
     

  • Muik A, Adams HC 3rd, Gieseke F, Altintas I, Schoedel KB, Blum JM, et al. DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity. J Immunother Cancer. 2022;10:e004322.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Galati D, Zanotta S. Empowering dendritic cell cancer vaccination: the role of combinatorial strategies. Cytotherapy. 2018;20:1309–23.

    Article 
    PubMed 

    Google Scholar
     

  • Song S, Wang Y, Wang J, Lian W, Liu S, Zhang Z, et al. Tumour-derived IL-10 within tumour microenvironment represses the antitumour immunity of Socs1-silenced and sustained antigen expressing. Eur J Cancer. 2012;48:2252–9.

    Article 
    PubMed 

    Google Scholar
     

  • Liu W, Kuang T, Liu L, Deng W. The role of innate immune cells in the colorectal cancer tumor microenvironment and advances in anti-tumor therapy research. Front Immunol. 2024;15:1407449.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Amin A, Dudek AZ, Logan TF, Lance RS, Holzbeierlein JM, Knox JJ, et al. Survival with AGS-003, an autologous dendritic cell-based immunotherapy, in combination with sunitinib in unfavorable risk patients with advanced renal cell carcinoma (RCC): Phase 2 study results. J Immunother Cancer. 2015;3:14.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Figlin RA, Tannir NM, Uzzo RG, Tykodi SS, Chen DYT, Master V, et al. Results of the ADAPT phase 3 study of rocapuldencel-T in combination with sunitinib as first-line therapy in patients with metastatic renal cell carcinoma. Clin Cancer Res J Am Assoc Cancer Res. 2020;26:2327–36.

    Article 

    Google Scholar
     

  • Weber R, Fleming V, Hu X, Nagibin V, Groth C, Altevogt P, et al. Myeloid-derived suppressor cells hinder the anti-cancer activity of immune checkpoint inhibitors. Front Immunol. 2018;9:1310.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Iclozan C, Antonia S, Chiappori A, Chen D-T, Gabrilovich D. Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer. Cancer Immunol Immunother CII. 2013;62:909–18.

    Article 
    PubMed 

    Google Scholar